Skip to main content

PD Dr. med. Christine Bernsmeier

Leitende Ärztin Gastroenterologie/Hepatologie

 

Portrait
Portrait
Lebenslauf
Mitgliedschaften
Publikationen
Lebenslauf

seit 2019 
Oberärztin Gastroenterologie/Hepatologie, Clarunis Universitäres Bauchzentrum Basel/
Standort Universitätsspital Basel

3/2018-12/2018
Oberärztin, Gastroenterologie & Hepatologie, Universitätsspital Basel

2016
Venia docendi der Universität Basel (Habilitation in Gastroenterologie, speziell Hepatologie)

01/2015-02/2018
Oberärztin Gastroenterologie & Hepatologie, Schwerpunkt Hepatologie, Kantonsspital St. Gallen

2012-2014
Clinical Research Fellow, Liver Intensive Therapy Unit, King’s College Hospital, London, UK

2012-2014
EASL Sheila Sherlock Postdoctoral Fellowship, Institute of Liver Studies, King’s College London, UK (Prof. J. Wendon)

2013
Schwerpunkt Titel Hepatologie FMH

2012
Facharzttitel Gastroenterologie FMH

07/2010-11/2012
Assistenzärztin Gastroenterologie & Hepatologie, Universitätsspital Basel

01/2010-06/2010
Oberärztin Innere Medizin, Universitätsspital Basel

2010
Facharzttitel Innere Medizin FMH

04/2008-12/2009
Assistenzärztin Innere Medizin, Universitätsspital Basel

04/2005-03/2008
Wissenschaftliche Assistenzärztin Hepatologie, Universitätsspital Basel

04/2005-03/2008
Promotion in Zellbiologie (Dr. phil., PhD), Hepatologie Labor, Universitätsspital Basel, Schweiz (Prof. M.H. Heim)

08/2004-03/2005
Assistenzärztin Innere Medizin, Universitätsspital Basel

02/2003-07/2004
Assistenzärztin Innere Medizin und Gastroenterologie & Hepatologie, Universitätsklinikum Kiel, Deutschland

1999-2002
Promotion in Medizin (Dr. med., MD) Labor für Gastroenterologie, Universitätsklinikum Kiel, Deutschland (Prof. U.R. Fölsch)

2000-2002
Auslandsaufenthalte an den Universitäten Montpellier (F), Lyon (F) und Basel (CH)

1996-2002
Medizinstudium, Martin-Luther Universität Halle-Wittenberg und Christian-Albrechts Universität Kiel, Deutschland

 

Mitgliedschaften

Federatio Medicorum Helveticorum (FMH)

Deutsche Gesellschaft für Innere Medizin (DGIM)

Schweizerische Gesellschaft für Gastroenterologie (SGG)

European Association for the Study of the Liver (EASL)

Swiss Association for the Study of the Liver (SASL)

British Association for the Study of the Liver (BASL)

European Association for the Study of the Liver - Chronic Liver Failure Consortium (EASL-CLIF)

Publikationen
  • Bernsmeier C, van der Merwe S, Périanin A. The innate immune cells in cirrhosis. J Hepatol. 2020 Mar 30. pii: S0168-8278(20)30189-6. doi: 10.1016/j.jhep.2020.03.027. [Epub ahead of print]
  • Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C.Life Sci Alliance. 2019 Dec 10;3(1). pii: e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan.
  • Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to Artemisia annua Tea. Ruperti-Repilado FJ, Haefliger S, Rehm S, Zweier M, Rentsch KM, Blum J, Jetter A, Heim M, Leuppi-Taegtmeyer A, Terracciano L, Bernsmeier C. Front Med (Lausanne). 2019 Oct 11;6:221. doi: 10.3389/fmed.2019.00221. eCollection 2019
  • Mensing B, Nowak A, Zweifel S, Terracciano L, Bernsmeier C, Filipowicz Sinnreich M. Morbus Wilson oder hepatolentikuläre Degeneration. Ther Umsch. 2018 Nov;75(4):241-248
  • Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG. CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair anti-microbial responses in patients with acute-on-chronic liver failure. Gut. Gut. 2018 Jun;67(6):1155-1167.
  • Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut. 2018 Feb;67(2):333-347.
  • Bernsmeier C. Die nicht-alkoholische Fettleber. Der informierte Arzt 2018; 01:15-17.
  • Bernsmeier C, Albano E, Liver dendritic cells and NAFLD evolution: A remaining open issue. J Hepatol. 2017 Jun;66(6):1120-1122.
  • Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. Increased Expression of CTLA4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Gastroenterology. 2017 Jul;153(1):263-276.e8.
  • Vergis N, Khamri W, Beale K, Sadiq F, Aletrari MO, Moore C, Atkinson SR, Bernsmeier C, Possamai LA, Petts G, Ryan JM, Abeles RD, James S, Foxton M, Hogan B, Foster GR, O'Brien AJ, Ma Y, Shawcross DL, Wendon JA, Antoniades CG, Thursz MR. Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase. Gut. 2017 Mar;66(3):519-529.
  • Bernsmeier C, Dill MT, Provenzano A, Makowska Z, Krol I, Muscogiuri G, Semela D, Tornillo L, Marra F, Heim MH, Duong FH. Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. Lab Invest. 2016 Sep;96(9):972-80.
  • Manakkat Vijay GK, Ryan JM, Abeles RD, Ramage S, Patel V, Bernsmeier C, Riva A, McPhail MJ, Tranah TH, Markwick LJ, Taylor NJ, Bernal W, Auzinger G, Willars C, Chokshi S, Wendon JA, Ma Y, Shawcross DL. Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure. Crit Care Med. 2016 Jan;44(1):43-53.
  • Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triatafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol. 2016 Jan;64(1):69-78.
  • Bernsmeier C, Singanayagam A, Patel VC, Wendon J, Antoniades CG. Immunotherapy in the treatment and prevention of infection in acute on chronic liver failure. Immunotherapy. 2015;7(6):641-54.
  • Bernsmeier C. Akute Dekompensation der Leberzirrhose und „acute-on-chronic“ Leberversagen. Leading Opinions Innere Medizin 2015; 6:84-87.
  • Bernsmeier C, Weisskopf DM, Pflueger MO, Mosimann J, Campana B, Terracciano L, Beglinger C, Heim MH, Cajochen C. Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls. PLoS One. 2015 Nov 17;10(11):e0143293
  • Campana B, Semela D, Heim M, Bernsmeier C. Non-alcoholic fatty liver disease - changing the prevalence of liver cancer? EMJ Hepatol. 2015; 3(1):12-18.
  • Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG. Patients with Acute on Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK. Gastroenterology. 2015 Mar;148(3):603-615.
  • Balmer ML, Slack E, de Gottardi A, Lawson MA, Hapfelmeier S, Miele L, Grieco A, Van Vlierberghe H, Fahrner R, Patuto N, Bernsmeier C, Ronchi F, Wyss M, Stroka D, Dickgreber N, Heim MH, McCoy KD, Macpherson AJ. The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Sci Transl Med. 2014 May 21;6(237):237ra66.
  • Bernsmeier C, Antoniades CG, Wendon J. What's new in acute liver failure? Intensive Care Med. 2014 Oct;40(10):1545-8.
  • Bernsmeier C, Meyer-Gerspach AC, Blaser LS, Jeker L, Steinert RE, Heim MH, Beglinger C. Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic Fatty liver disease. PLoS One. 2014 Jan 29;9(1):e87488.
  • Bernsmeier C, Calabrese D, Heim MH, Duong HT. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1. J Viral Hepat. 2014 Jan;21(1):9-18.
  • Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O'Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M. Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure. Hepatology. 2014 Apr;59(4):1564-76.
  • Huber X, Droeser RA, Bernsmeier C, Kirchhoff P. When a colonoscopy becomes a duodenoscopy: a palliative treatment of a malignant sigmoidoduodenal fistula. BMJ Case Rep. 2013 May 24;2013. pii: bcr2012008241. doi: 10.1136/bcr-2012-008241.
  • Rosin C, Bernsmeier C, Entenza J, Moreillon P, Frei R, Weisser M, Flückiger U. Daptomycin for highly resistant Enterococcus faecium infection. Swiss Med Wkly. 2012;Jun 26;142:0
  • Bernsmeier C et Heim MH. Non-alcoholic fatty liver disease and steatohepatitis: Hepatic manifestations of the metabolic syndrome. Swiss Med Forum. 2011;11(4):53-57.
  • Bernsmeier C, Filipowicz M, Terracciano L, Duong F, Heim MH. S-Adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse. PLoS One. 2010;Nov 8;5(11):e15492.
  • Bernsmeier C, Nickel C, Bingisser R, Kim MJ. Urinary tract infection presenting with nonspecific complaints and normal urinalysis in 84-year-old woman. The American Journal of Case Reports, 2010; 11: 116-118
  • Osthoff M, Bernsmeier C, Marsch SC, Hunziker PR. Levosimendan as treatment option in severe verapamil intoxication: a case report and review of the literature. Case Report Med. 2010;2010. pii: 546904.
  • Bernsmeier C et Heim MH. Insulin Resistance in Chronic Hepatitis C: Mechanisms and Clinical Relevance. Swiss Med Wkly 2009;139(47-48):678-684.
  • Bernsmeier C, Duong F, Christen V, Pugnale P, Negro F, Terracciano L, Heim MH. Virus induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. J Hepatol. 2008;49(3):429-40.
  • Christen V, Duong F, Bernsmeier C, Sun D, Nassal M, Heim MH. Inhibition of alpha interferon signaling by hepatitis B virus. J Virol 2007;81:159-165.
  • von Wagner M, Huber M, Berg T, Hinrichsen H, Rasenack J, Heintges T, Bergk A, Bernsmeier C, Häussinger D, Herrmann E, Zeuzem S. Peginterferon-alpha-2a (40KD) and ribavirin for 16 or 24 weeks in patients with genotype 2 or 3 chronic hepatitis C. Gastroenterology 2005;129:522-527.