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PD Dr. med. Silvio Däster

Oberarzt Viszeralchirurgie
Standort Universitätsspital Basel



Seit März 2020
Oberarzt Viszeralchirurgie, Clarunis – Universitäres Bauchzentrum Basel,
Standort Universitätsspital Basel

Fellowship in kolorektaler Chirurgie (Pelvic Exenteration, CRS/HIPEC),
Royal Prince Alfred Hospital, Sydney, Australien (Prof. M. Solomon)

Fellow of the European Board of Surgery, FEBS (Coloproctology)

Habilitation im Fach Allgemein- und Viszeralchirurgie, Universität Basel

Fellowship in kolorektaler Chirurgie
Concord Repatriation General Hospital, Concord, Sydney,
Australien (A/Prof. M. Rickard)

Oberarzt Viszeralchirurgie, Universitätsspital Basel (Prof. D. Oertli)

Stv. Oberarzt Viszeralchirurgie, Universitätsspital Basel (Prof. D. Oertli)

Specialty Registrar, Upper GI and Colorectal Surgery
Frimley Park Hospital NHS Foundation Trust, Frimley,
Surrey, UK (Mr. S. Singh, Mr. M. Gudgeon)

Facharzt für Chirurgie FMH

Forschungsaufenthalt, Institute for Surgical Research and Hospital Management (ICFS), Universitätsspital Basel (Prof. G. Spagnoli, Prof. M. Heberer)

Promotion (Dr. med.) über klinische Atherosklerose-Forschung, Universität Basel

Assistenzarzt Chirurgie, Universitätsspital Basel (Prof. D. Oertli)
mit zwei 12-monatigen Rotationen im Claraspital Basel (Prof. M. von Flüe)

Eidgenössisches Diplom in Humanmedizin

Studium der Humanmedizin, Universität Basel

  • Verbindung der Schweizer Ärztinnen und Ärzte (FMH)
  • Schweizerische Gesellschaft für Chirurgie (SGC)
  • American Association for Cancer Research (AACR)
  • European Society of Coloproctology (ESCP)
  • Solomon MJ, Daster S, Loizides S, Sutton P, Brown KGM, Austin KKS, Lee PJ: Access to the anterior pelvic compartment in pelvic exenteration in women – The interlabial approach: Video vignette. 2021: British Journal of Surgery 108: E268–E269.
  • Gräfitsch A, Kirchhoff P, Soysal SD, Däster S, Hoffmann H: Dynamic Serosal Perfusion Assessment during Colorectal Resection Using Visible Light Spectroscopy. 2021: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 62: 25–31.
  • Tosti N, Cremonesi E, Governa V, Basso C, Kancherla V, Coto-Llerena M, Amicarella F, Weixler B, Däster S, Sconocchia G, Majno PE, Christoforidis D, Tornillo L, Terracciano L, Ng CKY, Piscuoglio S, von Flüe M, Spagnoli G, Eppenberger-Castori S, Iezzi G, Droeser RA: Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer. Cancer Immunol Res. 2020; 8: 1452–1462
  • Lalos A, Tülek A, Tosti N, Mechera A, Wilhelm A, Soysal S, Däster S, Kancherla V, Weixler B, Spagnoli GC, Eppenberger-Castori S, Terracciano L, Piscuoglio S, von Flüe M, Posabella A, Droeser R: Prognostic significance of CD8+ T-Cells density in Stage III colorectal cancer depends on SDF-1 expression. Scientific Reports. 2020
  • Däster S, Eppenberger-Castori S, Mele V, Schäfer HM, Schmid L, Weixler B, Soysal SD, Droeser RA, Spagnoli GC, Kettelhack C, Oertli D, Terracciano L, Tornillo L, von Holzen U: Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis. Front Med (Lausanne). 2020 Apr 28; 7: 144
  • Solomon MJ, Loizides S, Däster S, Austin KKS, Lee PJ: Prone en bloc sacrectomy with proctectomy: a surgical approach to the inaccessible and hostile pelvis. Colorectal Dis. 2020; 22: 1440–1444
  • Tampakis A, Weixler B, Rast S, Tampaki EC, Cremonesi E, Kancherla, Tosti N, Kettelhack C, Ng KYC, Delko T, Soysal SD, von Holzen U, Tornillo L; Luigi Terracciano, Eppenberger-Castori S, Spagnoli G, Piscuoglio S, von Flüe M, Däster S, Droeser R; Cellular Oncology 2019
  • Angehrn F, Zeindler J, Droeser R, Däster S, Piscuoglio S, Ng CKY, Kilic E, Mechera R, Meili S, Isaak A, Weber WP, Muenst S, Soysal SD; Infiltration by myeloperoxidasepositive neutrophils is an independent prognostic factor in breast cancer.Breast Cancer Res Treat. 2019 Oct; 177(3): 581–589.
  • Däster S, Xiang H, Yang J, Rowe D, Keshava A, Rickard MJFX. High prevalence of asymptomatic internal hernias after laparoscopic anterior resection in a retrospective analysis of postoperative computed tomography. Int J Colorectal Dis. 2020
  • Haak F, Obrecht I, Tosti N, Weixler B, Mechera R, Däster S, von Strauss M, Delko T, Spagnoli GC, Terracciano L, Sconocchia G, von Flüe M, Kraljević M, Droeser RA. Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer. Cancer Control. 2020
  • Zeindler J, Angehrn F, Droeser R, Däster S, Piscuoglio S, Ng CKY, Kilic E, Mechera R, Meili S, Isaak A, Weber WP, Muenst S, Soysal SD. Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer. Breast Cancer Res Treat. 2019
  • Manfredonia C, Muraro MG, Hirt C, Mele V, Governa V, Papadimitropoulos A, Däster S, Soysal SD, Droeser RA, Mechera R, Oertli D, Rosso R, Bolli M, Zettl A, Terracciano LM, Spagnoli GC, Martin I, Iezzi G. Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor‐Based 3D Culture System. Advanced Biosystems. 2019
  • Mechera R, Soysal SD, Piscuoglio S, Ng CKY, Zeindler J, Mujagic E, Däster S, Glauser P, Hoffmann H, Kilic E, Droeser RA, Weber WP, Muenst S. Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer. BMC Cancer. 2019
  • Cremonesi E, Governa V, Garzon JFG, Mele V, Amicarella F, Muraro MG, Trella E, Galati-Fournier V, Oertli D, Däster SR, Droeser RA, Weixler B, Bolli M, Rosso R, Nitsche U, Khanna N, Egli A, Keck S, Slotta-Huspenina J, Terracciano LM, Zajac P, Spagnoli GC, Eppenberger-Castori S, Janssen KP, Borsig L, Iezzi G. Gut microbiota modulate T cell trafficking into human colorectal cancer. Gut. 2018
  • Ramser M, Eichelberger S, Däster S, Weixler B, Kraljević M, Mechera R, Tampakis A, Delko T, Güth U, Stadlmann S, Terracciano L, Droeser RA, Singer G. High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy. BMC Cancer. 2018
  • Weixler B, Renetseder F, Facile I, Tosti N, Cremonesi E, Tampakis A, Delko T, Eppenberger-Castori S, Tzankov A, Iezzi G, Kettelhack C, Soysal SD, von Holzen U, Spagnoli GC, Terracciano L, Tornillo L, Droeser RA, Däster S. Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer. Cell Oncol (Dordr). 2017
  • Governa V, Trella E, Mele V, Tornillo L, Amicarella F, Cremonesi E, Muraro MG, Xu H, Droeser R, Däster SR, Bolli M, Rosso R, Oertli D, Eppenberger-Castori S, Terracciano LM, Iezzi G, Spagnoli GC. The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer. Clin Cancer Res. 2017
  • Muenst S, Mechera R, Däster S, Piscuoglio S, Ng CKY, Meier-Abt F, Weber WP, Soysal SD. Pregnancy at early age is associated with a reduction of progesterone-responsive cells and epithelial Wnt signaling in human breast tissue. Oncotarget. 2017
  • Däster S, Amatruda N, Calabrese D, Ivanek R, Turrini E, Droeser RA, Zajac P, Fimognari C, Spagnoli GC, Iezzi G, Mele V, Muraro MG. Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment. Oncotarget. 2017
  • Däster S, Soysal SD, Koechlin L, Stoll L, Peterli R, von Flüe M, Ackermann C. Perioperative outcomes of esophageal cancer surgery in a mid-volume institution in the era of centralization. Langenbecks Arch Surg. 2016
  • Droeser RA, Mechera R, Däster S, Weixler B, Kraljević M, Delko T, Güth U, Stadlmann S, Terracciano L, Singer G. MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity. BMC Cancer. 2016
  • Däster S, Eppenberger-Castori S, Hirt C, Soysal SD, Delko T, Nebiker CA, Weixler B, Amicarella F, Iezzi G, Governa V, Padovan E, Mele V, Sconocchia G, Heberer M, Terracciano L, Kettelhack C, Oertli D, Spagnoli GC, von Holzen U, Tornillo L, Droeser RA. Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis. Oncoimmunology. 2015
  • Weixler B, Cremonesi E, Sorge R, Muraro MG, Delko T, Nebiker CA, Däster S, Governa V, Amicarella F, Soysal SD, Kettelhack C, von Holzen UW, Eppenberger-Castori S, Spagnoli GC, Oertli D, Iezzi G, Terracciano L, Tornillo L, Sconocchia G, Droeser RA. OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer. Oncotarget. 2015
  • Däster S, Eppenberger-Castori S, Hirt C, Zlobec I, Delko T, Nebiker CA, Soysal SD, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Spagnoli GC, Kettelhack C, Terracciano L, Oertli D, von Holzen U, Tornillo L, Droeser RA. High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Dis Markers. 2014
  • Angehrn FV, Däster S, Antonescu M. Massive surgical emphysema after perineal proctosigmoidectomy. BMJ Case Rep. 2014
  • Däster S, Soysal SD, Stoll L, Peterli R, von Flüe M, Ackermann C. Long-term quality of life after Ivor Lewis esophagectomy for esophageal cancer. World J Surg. 2014
  • Muenst S, Schaerli AR, Gao F, Däster S, Trella E, Droeser RA, Muraro MG, Zajac P, Zanetti R, Gillanders WE, Weber WP, Soysal SD. Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer. Breast Cancer Res Treat. 2014
  • Däster S, Droeser RA, Delko T, Oertli D. Two similar cases of internal hernia after laparoscopic Roux-en-Y gastric bypass surgery. BMJ Case Rep. 2013
  • Muenst S, Däster S, Obermann EC, Droeser RA, Weber WP, von Holzen U, Gao F, Viehl C, Oertli D, Soysal SD. Nuclear expression of snail is an independent negative prognostic factor in human breast cancer. Dis Markers. 2013
  • Däster S, Nebiker CA, Hohmann J, Droeser RA. Missed diagnosis of a gallstone ileus: an incomplete laparoscopy due to a putative ventriculoperitoneal shunt infection. BMJ Case Rep. 2013
  • Muraro MG, Mele V, Däster S, Han J, Heberer M, Cesare Spagnoli G, Iezzi G. CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines. Stem Cells Transl Med. 2012
  • Däster S, Borbély Y, Peterli R. Acute pancreatitis after Roux-en-Y gastric bypass surgery due to reflux into biliopancreatic limb. Surg Obes Relat Dis. 2012